Understanding MTHFR: What It Is and Why It Matters

MTHFR Genetic Mutation: Associated Health Complications Including Chronic Fatigue, Migraines, and varies cacner.

If you've been exploring genetic health or have had DNA testing, you may have come across the term MTHFR. It’s not as complicated as it sounds—but it is important. This blog will break it down in a simple, easy-to-understand way so you can make sense of what MTHFR means for your health.

What Is MTHFR?

MTHFR stands for Methylenetetrahydrofolate Reductase, which is an enzyme that plays a critical role in how your body processes folate (vitamin B9). This enzyme is essential for a process called methylation, which affects everything from your DNA repair to neurotransmitter production.

In short, MTHFR helps convert folate into a usable form that your body needs to function properly.

MTHFR Gene Variants (Mutations)

Some people have variations (called polymorphisms or mutations) in the MTHFR gene, the instructions your body uses to make the MTHFR enzyme. The two most common variants are:

• C677T

• A1298C

  
  

You can inherit these from one or both parents. People with one variant (heterozygous) typically don’t have major issues, while those with two variants (homozygous) may have a reduced ability to process folate and methylate properly.

Why Does MTHFR Matter?

Impaired MTHFR function may contribute to a variety of health issues, including:

• Elevated homocysteine levels, which can increase the risk of heart disease

• Chronic Fatigue and brain fog

• Anxiety or depression

• Fertility: Pregnancy complications, such as miscarriage or neural tube defects

• Poor detoxification

• ADHD

• Autism

• Dementia

• Inflammation

• Varies Cancers

  
  

It’s important to note: not everyone with an MTHFR variant will have health problems. But knowing your status can help guide nutritional and lifestyle choices.

How Do You Know If You Have an MTHFR Variant?

You can get tested through:

• Your Naturopath, Functional Nutritionist and your Doctor

  
  

Once you know your MTHFR status, you can make informed decisions about your health.

Supporting Your Body If You Have an MTHFR Variant

Here are some practical tips:

Choose the Right Supplements

• Look for methylated forms of B vitamins:

  • Methylfolate instead of folic acid

  • Methylcobalamin (B12)

• Avoid synthetic folic acid, which may be poorly processed by those with MTHFR variants.

  
  

Eat a Nutrient-Rich Diet

• Leafy greens, beans, lentils, asparagus, and liver are great folate sources.

• Reduce processed foods and added sugars, and Fortified food with Folic acid (such as flour

Support Detoxification

• Drink plenty of water

• Sweat (exercise or sauna)

• Eat cruciferous vegetables (like broccoli, cauliflower, kale)

Manage Stress

Methylation affects neurotransmitters, so supporting mental health through mindfulness, sleep, and regular exercise can make a big difference.

Final Thoughts

MTHFR is just one piece of your health puzzle. While it can impact how your body uses folate and processes toxins, having a gene variant isn’t a life sentence—it’s an opportunity for personalized health care.

If you suspect MTHFR may be a factor in your health or want to explore it further, talk to a healthcare provider who understands genetic testing and functional nutrition.

Knowledge is power and when it comes to your genes, it’s also the key to optimizing your health.

For your best health, Always,

Saphy Moussa N.D.